Although we can acquire or achieve with impressive frequency, although we can discard or dodge with admirable efficiency, the holes we fill and blights we escape always give way to new ones! There is no end to satisfying our wants or escaping our dislikes, but there is a deeper current to this stream of life.
The Buddha was committed to alleviating human suffering. Careful meditation on impermanence reveals the deepest truth: no durable self exists. You are among the “things” that seem stable but are actually juggled, fleeting aspects of an undivided flux. If there is no “you,” then who suffers?